Research Studies

Learn more about what 'Opu Probiotics does for the body by reading more about our supplement claims and the research that backs them up.

1. “Survives passage through the stomach and grows/thrives in the small intestine”

Reference: Colom J, Freitas D, Simon A, Brodkorb A, Buckley M, Deaton J and Winger AM (2021) Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study. Front. Microbiol. 12:715863. doi: 10.3389/fmicb.2021.715863

Full Study Link: https://www.frontiersin.org/articles/10.3389/fmicb.2021.715863/full

2. “Grows in the small intestines within hours after consumption”

Reference: Colom J, Freitas D, Simon A, Brodkorb A, Buckley M, Deaton J and Winger AM (2021) Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study. Front. Microbiol. 12:715863. doi: 10.3389/fmicb.2021.715863

Full Study Link: https://www.frontiersin.org/articles/10.3389/fmicb.2021.715863/full

3. “Supports regularity”

Reference: Cuentas, Ana Maria, et al. “The Effect of Bacillus Subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity.” Journal of Probiotics & Health, vol. 05, no. 04, 2017, doi:10.4172/2329-8901.1000189.

Full Study Link: https://www.longdom.org/open-access/the-effect-of-bacillus-subtilis-de111-on-the-daily-bowel-movementprofile-for-people-with-occasional-gastrointestinal-irregularity-2329-8901-1000189.pdf

4. “Supports normal bowel movements”

Reference: Cuentas, Ana Maria, et al. “The Effect of Bacillus Subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity.” Journal of Probiotics & Health, vol. 05, no. 04, 2017, doi:10.4172/2329-8901.1000189.

5. “Helps protect against occasional constipation or diarrhea”

Reference: Cuentas, Ana Maria, et al. “The Effect of Bacillus Subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity.” Journal of Probiotics & Health, vol. 05, no. 04, 2017, doi:10.4172/2329-8901.1000189.

Full Study Link: https://www.longdom.org/open-access/the-effect-of-bacillus-subtilis-de111-on-the-daily-bowel-movementprofile-for-people-with-occasional-gastrointestinal-irregularity-2329-8901-1000189.pdf

6. “Supports heart health”

Reference: Trotter, R.E., Vazquez, A.R., Grubb, D.S., Freedman, K.E., Grabos, L.E., Jones, S., Gentile, C.L., Melby, C.L., Johnson, S.A., Wier, T.L. 2020 Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes: 11 (7)- Pages: 621 - 630

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33161737/

7. “Promotes a healthy heart”

Reference: Trotter, R.E., Vazquez, A.R., Grubb, D.S., Freedman, K.E., Grabos, L.E., Jones, S., Gentile, C.L., Melby, C.L., Johnson, S.A., Wier, T.L. 2020 Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes: 11 (7)- Pages: 621 - 630

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33161737/

8. “Supports cardiovascular health”

Reference: Trotter, R.E., Vazquez, A.R., Grubb, D.S., Freedman, K.E., Grabos, L.E., Jones, S., Gentile, C.L., Melby, C.L., Johnson, S.A., Wier, T.L. 2020 Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes: 11 (7)- Pages: 621 - 630

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33161737/

9. “Promotes blood lipid balance consistent with good health”

Reference: Trotter, R.E., Vazquez, A.R., Grubb, D.S., Freedman, K.E., Grabos, L.E., Jones, S., Gentile, C.L., Melby, C.L., Johnson, S.A., Wier, T.L. 2020 Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes: 11 (7)- Pages: 621 - 630

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33161737/

10. “Supports a total blood cholesterol level already within normal range”

Reference: Trotter, R.E., Vazquez, A.R., Grubb, D.S., Freedman, K.E., Grabos, L.E., Jones, S., Gentile, C.L., Melby, C.L., Johnson, S.A., Wier, T.L. 2020 Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes: 11 (7)- Pages: 621 - 630

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33161737/

11. “Promotes a total cholesterol and cholesterol balance that supports health”

Reference: Trotter, R.E., Vazquez, A.R., Grubb, D.S., Freedman, K.E., Grabos, L.E., Jones, S., Gentile, C.L., Melby, C.L., Johnson, S.A., Wier, T.L. 2020 Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes: 11 (7)- Pages: 621 - 630

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33161737/

12. “Supports immune health”

Reference: Freedman, K.E.; Hill, J.L.; Wei, Y.; Vazquez, A.R.; Grubb, D.S.; Trotter, R.E.; Wrigley, S.D.; Johnson, S.A.; Foster, M.T.; Weir, T.L. Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111. Int. J. Mol. Sci. 2021, 22, 2453. https://doi.org/10.3390/ijms22052453

Full Study Link: https://www.mdpi.com/1422-0067/22/5/2453

13. “Supports a robust immune system function that naturally supports good health”

Reference: Freedman, K.E.; Hill, J.L.; Wei, Y.; Vazquez, A.R.; Grubb, D.S.; Trotter, R.E.; Wrigley, S.D.; Johnson, S.A.; Foster, M.T.; Weir, T.L. Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111. Int. J. Mol. Sci. 2021, 22, 2453. https://doi.org/10.3390/ijms22052453

Full Study Link: https://www.mdpi.com/1422-0067/22/5/2453

14. “Promotes a healthy immune system and response that helps to support good health naturally”

Reference: Freedman, K.E.; Hill, J.L.; Wei, Y.; Vazquez, A.R.; Grubb, D.S.; Trotter, R.E.; Wrigley, S.D.; Johnson, S.A.; Foster, M.T.; Weir, T.L. Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111. Int. J. Mol. Sci. 2021, 22, 2453. https://doi.org/10.3390/ijms22052453

Full Study Link: https://www.mdpi.com/1422-0067/22/5/2453

15. “Promotes urinary tract health”

Reference: Labellarte, G. and Maher, M. (2019) Tolerance and Effect of a Probiotic Supplement Delivered in Capsule Form. Food and Nutrition Sciences, 10, 626-634. Doi:10.4236/fns.2019.106046

Full Study Link: https://www.scirp.org/journal/paperinformation.aspx?paperid=93173

16. “Supports normal fat metabolism”

Reference: Toohey, J. C., Townsend, J. R., Johnson, S. B., Toy, A. M., Vantrease, W. C., Bender, D., Mangine, G. T. (2018). Effects of Probiotic (Bacillus subtilis) Supplementation During Offseason Resistance Training in Female Division I Athletes. Journal of Strength and Conditioning Research,1. doi:10.1519/jsc.0000000000002675

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/33105368/

17. “Supports improved results and performance with strength training”

18. “Supports exercise recovery”

Reference: Townsend, J., Bender, D., Vantrease, W., Sapp, P., Toy, A., Woods, C., & Johnson, K. (2018). Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players. Sports, 6(3), 70. doi:10.3390/sports6030070

Full Study Link: https://pubmed.ncbi.nlm.nih.gov/30049931/

Research Studies

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